Drowsiness or paradoxical reaction, which can present with hallucinations.Other than this supportive treatment, gastric lavage and induced emesis (vomiting) are usually recommended as treatments for oral overdoses. Physostigmine, a cholinergic drug that readily crosses the blood-brain barrier, has been used as an antidote to treat the central nervous system depression symptoms of a scopolamine overdose. Unknown frequency adverse effects include: Rare (<0.1% incidence) adverse effects include: Tachycardia (usually occurs at higher doses and is succeeded by bradycardia).Anhidrosis (reduced ability to sweat to cool off).Uncommon (0.1–1% incidence) adverse effects include: Adverse effects Īdverse effect incidence: Scopolamine use should be avoided in this age group because of these potent anticholinergic adverse effects, which have also been linked to an increased risk for dementia. This phenomenon is especially true for older people who are also on several other medications. The likelihood of experiencing adverse effects from scopolamine is increased in the elderly relative to younger people. Although no human studies exist to document the safety of scopolamine while nursing, the manufacturer recommends that caution be taken if scopolamine is administered to a breastfeeding woman. Scopolamine enters breast milk by secretion. It is sometimes used as a premedication, (especially to reduce respiratory tract secretions) in surgery, most commonly by injection. Aid in gastrointestinal radiology and endoscopy.Motion sickness, including sea sickness, leading to its use by scuba divers (where it is often applied as a transdermal patch behind the ear).Scopolamine has a number of uses in medicine where it is used in low doses to treat: It is on the World Health Organization's List of Essential Medicines. The name "scopolamine" is derived from one type of nightshade known as Scopolia, while the name "hyoscine" is derived from another type known as Hyoscyamus niger. Scopolamine is also the main active component produced by certain plants of the nightshade family, which historically have been used as psychoactive drugs (known as deliriants) due to their antimuscarinic-induced hallucinogenic effects. ![]() These alkaloids when used in combination gave rise to a synergistic state called " twilight sleep". Around this time it was first proposed for and then subsequently used for years to induce amnesia and synergistic pain relief during childbirth by administering a combination of both scopolamine and morphine. ![]() Scopolamine was first written about in 1881 and started to be used for anesthesia around 1900. Scopolamine is in the antimuscarinic family of drugs and works by blocking some of the effects of acetylcholine within the nervous system. ![]() Whether its use during pregnancy is safe remains unclear, and use during breastfeeding is still cautioned by health professionals and manufacturers of the drug. It is not recommended in people with angle-closure glaucoma or bowel obstruction. Ĭommon side effects include sleepiness, blurred vision, dilated pupils, and dry mouth. It may also be used orally and as a transdermal patch. When used by injection, effects begin after about 20 minutes and last for up to 8 hours. It is also sometimes used before surgery to decrease saliva. Scopolamine, also known as hyoscine, or Devil's Breath, is a natural or synthetically produced tropane alkaloid and anticholinergic drug that is formally used as a medication for treating motion sickness and postoperative nausea and vomiting.
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